Rep. Darrell Issa, who is leading a probe into the Fast and Furious Mexican gunrunning scandal, launched a scathing attack on Attorney General Eric Holder on Monday, accusing him of being incompetent, untrustworthy and negligent.

In a letter to Holder, the California Republican named two senior officials in the Department of Justice he contends were fully aware of the project that allowed hundreds of high-powered weapons to fall into the hands of Mexican drug cartels.

Three Republican House members have called for Holder’s resignation and, although Issa did not go quite that far, he made it clear that responsibility for the botched scheme must fall on his shoulders.

“Whether you realize yet or not, you own Fast and Furious. It is your responsibility,â€