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  1. #1
    Senior Member JohnDoe2's Avatar
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    Trump taking unproven drug hydroxychloroquine

    Coronavirus: Trump taking unproven drug hydroxychloroquine

    • 4 minutes ago

    US President Donald Trump has said he is taking hydroxychloroquine - which health officials have warned may be unsafe - to ward off coronavirus.

    Speaking at the White House, he told reporters he started taking the malaria and lupus medication recently.

    "I'm taking it for about a week and a half now and I'm still here, I'm still here," he said.

    There is no evidence hydroxychloroquine can fight off coronavirus, though clinical trials are under way.

    Asked on Monday what was his evidence of the drug's positive benefits, Mr Trump said: "Here's my evidence, I get a lot of positive calls about it."

    The president - who has repeatedly touted hydroxychloroquine - suggested many medical workers were also taking the drug.

    "You'd be surprised at how many people are taking, and especially the frontline workers before you catch it, the frontline workers many, many are taking it," he told reporters.

    The US Food and Drug Administration (FDA) last month issued an advisory that hydroxychloroquine has "not been shown to be safe and effective".

    It cited reports that the drug can cause serious heart rhythm problems in Covid-19 patients.

    The FDA warned against use of the medication outside hospitals, where the agency has granted temporary authorisation for its use if clinical trials are unavailable.


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  2. #2
    Senior Member Captainron's Avatar
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    I discussed this with my doctor and we figured that it might be something that controls symptoms, not necessarily halting the virus. One of the big downsides to COVID is that the immune system tends to overrreact, making the cure sometimes worse than the disease. I got a flu shot in late December, which is intended to produce antibodies. So when exposed to the COVID might have caused a bigger reaction than otherwise. 80 percent of people infected have light symptoms.
    "Men of low degree are vanity, Men of high degree are a lie. " David
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  3. #3
    Senior Member JohnDoe2's Avatar
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    'This will kill you': People are warning others following Trump's apparent use of hydroxychloroquine

    Savannah Behrmann, USA TODAY
    ,USA TODAYMay 18, 2020

    WASHINGTON – President Donald Trump announced Monday he is taking hydroxychloroquine, a drug unproven against the coronavirus. Soon after, "Flintstone Vitamins" began trending on Twitter.

    But, many doctors, journalists and politicians issued stern warnings after the president's revelation.

    Trump, who said he has tested negative for COVID-19, said he has been taking hydroxychloroquine daily for about a week and a half as an added measure to avoid getting the coronavirus. He said the White House physician "didn't recommend" hydroxychloroquine but offered it to him.

    He has repeatedly touted the drug as a treatment for coronavirus, despite little concrete evidence it effectively treats the disease. There is no data to support the notion that hydroxychloroquine helps people infected with SARS-CoV-2, the virus that causes COVID-19.

    More: Can hydroxychloroquine prevent COVID-19? President Trump thinks maybe. There's no data to support that.

    Fox News anchor Neil Cavuto warned of taking hydroxychloroquine, saying it could kill people who are in certain health risk populations.

    "The fact of the matter is though, when the president said 'what have you got to lose?', in a number of studies, those certain vulnerable population has one thing to lose: their lives," Cavuto said.

    He continued, "I cannot stress enough. This will kill you. So, again, whatever benefits the president says this has, and certainly it has had for those suffering from malaria, dealing with lupus, this is a leap that should not be taking casually by those watching from home or assuming well the president of the United States says it's ok."

    Aaron Rupar


    Fox News's Neil Cavuto is stunned by Trump's announcement that he's taking hydroxychloroquine: "If you are in a risky population here, and you are taking this as a preventative treatment ... it will kill you. I cannot stress enough. This will kill you."

    1:43 PM - May 18, 2020
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    A few studies have shown the drug has not been effective against COVID-19, and some point to an increase in heart problems.

    Sen. Warren on brother's COVID-19 death:
    'It just feels like something that didn't have to happen'

    The FDA has cautioned that hydroxychloroquine should be limited to people in clinical trials, which are carefully overseen, or who are hospitalized, due to concerns about the potentially dangerous adverse effects. Trump appears to be taking it as a prophylactic, with the thought it could prevent someone exposed to coronavirus from getting it.

    "Hydroxychloroquine and chloroquine have not been shown to be safe and effective for treating or preventing COVID-19," the FDA warned. Both can cause abnormal heart rhythms and a dangerously rapid heart rate, the statement said.

    Dr. Leana Wen, an emergency physician and former health commissioner for Baltimore, tweeted that "There is NO evidence for hydrochloroquine being effective in treatment of #covid19 or prophylaxis to prevent the disease."

    "This is a medication that has serious side effects. I am very concerned about @realDonaldTrump continuing to model behavior that could harm many Americans," she concluded.

    Donald Trump will tour Ford plant in Michigan that makes ventilators for coronavirus response

    More: When a coronavirus vaccine is developed, who will be first in line to get it? A CDC panel usually decides

    Senator Brian Schatz, D-Hawaii, tweeted, "I took hydroxychloroquine too. For malaria, 28 years ago. Because I am not a lunatic."

    Congressman Tim Ryan, D-Ohio, who briefly ran to be the 2020 Democratic nominee, warned followers to not self-medicate with the drug, and posted that,

    "The FDA has repeatedly warned against taking hydroxychloroquine. It has potentially deadly side effects."

    Tim Ryan


    US House candidate, OH-13


    The FDA has repeatedly warned against taking hydroxychloroquine. It has potentially deadly side effects.

    I can't stress this enough: Do NOT self-medicate with it.

    3:16 PM - May 18, 2020
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    Trump's top health advisers – Anthony Fauci and Deborah Birx – showed up at a White House event last Friday with protective masks, though the president himself continued to avoid using any facial protection in public.

    Anthony Fauci, Deborah Birx wear masks, Trump doesn't in address on coronavirus vaccines

    Some on Twitter took their criticism of Trump's reveal a step further on Monday, using GIFs and references to Flintstones Vitamins to express their disbelief:

    flavortown alderman@jesseltaylor

    They're definitely giving him children's vitamins and telling him they're a COVID-19 cure …

    Jeff Mason


    .⁦@realDonaldTrump⁩ says he is taking #Hydroxychloroquine

    1:30 PM - May 18, 2020
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    Oliver Willis


    "mr president, here is your daily dose of hydroxychloroquine"
    "i feel stronger already"
    (h/t @jesseltaylor)


    1:34 PM - May 18, 2020
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    David Frum


    · 6h

    "Could we get a list of all the drugs the president currently is taking?"

    Kevin Ostapek@kostapek

    There’s a very good chance White House doctors are giving @realDonaldTrump sugar pills or, Flintstones vitamins and telling him it’s hydroxychloroquine.


    2:47 PM - May 18, 2020
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    Bill Grueskin@BGrueskin

    "Yes, Mr. President, this is the Flintstones Chewable Hydoroxychloroquine tablet. Take as many as you want!"


    1:33 PM - May 18, 2020
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    Contributing: Courtney Subramanian, John Fritze, Elizabeth Weise, David Jackson

    This article originally appeared on USA TODAY: COVID-19: Trump claims he is taking hydroxychloroquine

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  4. #4
    Senior Member JohnDoe2's Avatar
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    President Trump has common form of heart disease

    By Dr. Sanjay Gupta, CNN Chief Medical Correspondent

    Updated 3:03 PM ET, Thu February 1, 2018

    (CNN)Like most men of his age, President Donald Trump has a common form of heart disease, relatively easy to address if he increases the dose of his cholesterol-lowering medication and makes necessary lifestyle changes. Without those changes, the President has a moderate risk of having a heart attack in the next three to five years, according to the Mayo Clinic.

    On Tuesday, White House physician Dr. Ronny Jackson disclosed Trump's basic labs measurements, physical exam results and the conclusion of a cognitive exam, known as the Montreal Cognitive Assessment.

    Additionally, the President had an echocardiogram of his heart, as well as a stress test, both described as normal. Although it was not part of the official medical records that were released yesterday, after further questioning, Jackson also revealed that Trump underwent a coronary calcium CT scan as part of his routine physical exam.

    The President is overweight and doesn't exercise much, like most Americans

    His score is 133, and anything over 100 indicates plaque is present and that the patient has heart disease.

    According to Trump's official medical records, in 2009 his coronary calcium score was 34. In 2013, it was 98.

    Most people might have not heard of this test, also known simply as a heart scan or calcium score. It is a CT scan, a specialized X-ray that takes high quality pictures of the heart, looking for calcium-containing plaque in the blood vessels that feed the heart, known as the coronaries. With this information, doctors can then calculate the risk of having a heart problem in the future. In the case of Trump, a new score of 133 reveals there has been a steady build-up of plaque in his blood vessels, indicating moderate heart disease. Also concerning are Trump's total cholesterol levels and his LDL ("bad" cholesterol), as both increased significantly over the last year, despite being on a statin drug known as Crestor or Rosuvastatin.

    Trump, 71, is not too different than most Americans his age. After the age of 40, most men in the United States have some evidence of heart disease, and the President's score places him squarely in the mid-risk range for a man of his age. Because the President doesn't smoke or drink and "appears to have good genes," according to Jackson, he has been able to avoid the classic symptoms of heart disease.

    "His score is 133 and he is 71 years of age, which puts him in the 46 percentile," said cardiologist Dr. Rachel Bond of Lenox Hill Hospital in New York. "What does this indicate? Yes, he certainly has coronary artery disease because calcium is present. But this is also common for someone his gender, race and age.

    "When I compare him to other males who are 71 and white, only 46% of others have a better score than him."

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    See the latest news and share your comments with CNN Health on Facebook and Twitter.

    Bond added this is not something to be taken lightly.

    A coronary calcium score below 100 reduces the risk of heart attack to moderate.

    Jackson has already increased the dosage of the Trump's cholesterol-lowering medication and recommended a low-carbohydrate and low-fat diet, along with an exercise regimen.

    Clarification: Additional information about coronary calcium scores has been added to this story.


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  5. #5
    Super Moderator imblest's Avatar
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    Thousands of Doctors: Yes, Hydroxychloroquine Works Against Wuhan Coronavirus

    Katie Pavlich
    Posted: Apr 06, 2020 2:30 PM
    Share Tweet

    Over the past three weeks, there's been debate over whether hydroxychloroquine, a drug used for decades to treat malaria, can help ease the symptoms of Wuhan coronavirus. During White House press briefings, reporters have done their best to shoot down the possibility.

    But doctors around the country and the world are using it and seeing positive results.

    First, in Los Angeles:
    Dr. Anthony Cardillo said he has seen very promising results when prescribing hydroxychloroquine in combination with zinc for the most severely-ill COVID-19 patients.
    "Every patient I've prescribed it to has been very, very ill and within 8 to 12 hours, they were basically symptom-free," Cardillo told Eyewitness News. "So clinically I am seeing a resolution."
    Cardillo is the CEO of Mend Urgent Care, which has locations in Sherman Oaks, Van Nuys and Burbank.
    He said he has found it only works if combined with zinc. The drug, he said, opens a channel for the zinc to enter the cell and block virus replication.
    "We have to be cautious and mindful that we don't prescribe it for patients who have COVID who are well," Cardillo said. "It should be reserved for people who are really sick, in the hospital or at home very sick, who need that medication. Otherwise we're going to blow through our supply for patients that take it regularly for other disease processes."

    New York
    Dr. Mohammud Alam, an infectious disease specialist affiliated with Plainview Hospital, said 81 percent of infected covid patients he treated at three Long Island nursing homes recovered from the contagion.
    “In this crisis, I realized I had to do something,” Alam said. ”I realized if this was my dad, what would I do? And I would do anything I could to help.”
    Alam said he decided he could not apply the touted combination of the antimalarial hydroxychloroquine and antibiotic azithromycin because the side effects could be potentially fatal for his high-risk patients, many of whom had underlying heart issues.
    So instead, Alam replaced azithromycin with another decades-old antibiotic that doesn’t pose any known risks to the heart.

    New Jersey
    Dr. Stephen Smith, founder of The Smith Center for Infectious Diseases and Urban Health, said on “The Ingraham Angle” on Wednesday night that he is optimistic about the use of antimalarial medications and antibiotics to treat COVID-19 patients, calling it “a game-changer.”
    Smith, who is treating 72 COVID-19 patients, said that he has been treating "everybody with hydroxychloroquine and azithromycin [an antibiotic]. We’ve been doing so for a while.”
    He pointed out that not a single COVID-19 patient of his that has been on the hydroxychloroquine and azithromycin regimen for five days or more has had to be intubated.

    Around the world
    An international poll of thousands of doctors rated the Trump-touted anti-malaria drug hydroxychloroquine the best treatment for the novel coronavirus.
    Of the 6,227 physicians surveyed in 30 countries, 37 percent rated hydroxychloroquine the “most effective therapy” for combating the potentially deadly illness, according to the results released Thursday.
    The survey, conducted by the global health care polling company Sermo, also found that 23 percent of medical professionals had prescribed the drug in the US — far less than other countries.
    "Outside the US, hydroxychloroquine was equally used for diagnosed patients with mild to severe symptoms whereas in the US it was most commonly used for high risk diagnosed patients,” the survey found.
    The medicine was most widely used in Spain, where 72 percent of physicians said they had prescribed it.

    It's working, which is why President Trump is touting its use.
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  6. #6
    Super Moderator imblest's Avatar
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    North Carolina
    39 elderly Texans successfully complete hydroxychloroquine treatment for COVID-19, doctor says

    Patients completed a five-day treatment and their doctor said none of the patients experienced side effects.

    Author: Jason Whitely
    Published: 5:52 PM CDT April 14, 2020
    Updated: 6:38 PM CDT April 14, 2020

    DALLAS — What happened at a Galveston County nursing home over the last week was one of the first big tests of hydroxychloroquine to treat COVID-19 patients in Texas.

    “I thought the risk of seeing 15% of that nursing home die was just not an acceptable,” said Dr. Robin Armstrong, MD, medical director at The Resort at Texas City.

    Fifty-six residents at this senior facility in Galveston County contracted the novel coronavirus. Dr. Robin Armstrong said 39 of them gave him permission to treat them with hydroxychloroquine pills.

    “Most of the patients have done well. And, you know, and I think that that is suggestive that the medication is helpful,” Armstrong told WFAA.

    But notice that Armstrong qualified his answer by saying “most of the patients.”

    “Well, I would say I would say all the patients have done well,” Armstrong added.

    On Sunday, those 39 patients finished five days of treatment with hydroxychloroquine. Dr. Armstrong said no one experienced any side effects.

    “We've got one patient now that kind of goes back and forth,” said Dr. Armstrong, “He's an older gentleman, but we're kind of nursing him through the process, but he's getting better.

    Two patients receiving hydroxychloroquine have had to go to hospital for unrelated conditions, Armstrong disclosed; a woman had a fall and a man got dehydrated in his room because he was not eating and drinking.

    But for the first time since this treatment began, many of those who have recovered from the virus have been able to go outside and get some fresh air over the last 48 hours, Armstrong said.

    The 65-year-old anti-malarial drug became controversial after Pres. Trump said it was a promising possibility for COVID-19 patients.

    Dr. Armstrong is a Republican activist and said he supports the president, but at first questioned whether hydroxychloroquine would work for patients with coronavirus symptoms.

    “When this hydroxychloroquine came out, I was a bit skeptical,” he explained, “because I know the World Health Organization actually was not initially including it in their study, because they didn't think that it was very effective.”

    Democrats have correctly cautioned that hydroxychloroquine remains unproven for treating the coronavirus.

    But if the president didn't bring attention to this drug, it’s doubtful there would be any political controversy around this pharmaceutical.

    “I don't think so,” Armstrong said. “I don't think this would even be a conversation, honestly.”

    Supply and demand have created a new side effect in the market for these tablets.

    “I’ve been on this medication for about 20 years or so,” said Sandy Dixon, who lives in Euless in Tarrant County.

    Hydroxychloroquine helps her live with lupus, but she says the pills have become harder for her to find since some doctors began using them for coronavirus patients.

    “I understand for them it’s an ‘if’ but for me it’s not an ‘if’ factor. I need the medicine every day to be able to function.”

    A Kroger spokesperson told WFAA that its Texas pharmacies have hydroxychloroquine in stock.

    CVS and Walgreens said it’s now limiting these pills to ensure everyone with a prescription gets some.

    Messages to both WalMart and Tom Thumb have not been returned.

    Armstrong is quick to note that hydroxychloroquine is not a cure for COVID-19 but he said, in his experience, it can help reduce the severity of the symptoms in some patients.

    ~Video at source link.

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  7. #7
    Senior Member JohnDoe2's Avatar
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    Hydroxychloroquine Not Recommended for COVID-19 by The National Institutes of Healthy

    April 23, 2020

    This week, the National Institutes of Health issued treatment guidelines for the management of COVID-19. It does not include the use of pharmaceutical agents for pre or post-exposure prophylaxis, including hydroxychloroquine, except for within the confines of a clinical trial.

    This comes as good news to the rheumatology community which was already struggling with securing sufficient supplies of hydroxychloroquine for lupus and rheumatoid arthritis patients who rely on the treatment to control flares. Demand for the drug spiked in early March after President Trump championed it's use to treat patients with COVID-19 despite the lack of supporting scientific evidence. The treatment eventually became standard practice for COVID-19 patients in hospitals across the country while rheumatology patients found it increasingly difficult to fill prescriptions for hydroxychloroquine.

    In fact, the NIH consensus panel states there is no current specific treatment for people with a suspected or confirmed, asymptomatic or pre-symptomatic SARS-CoV-2 infection. However, there are hundreds of clinical trials underway, which, in addition to hydroxychloroquine, includes chloroquine, and remdesivir.

    Laboratory findings of COVID-19 patients have revealed the presence of leukopenia, and elevations in aminotransferase levels, C-reactive protein, D-dimer, ferritin, and lactate dehydrogenase. Chest X-rays can vary, but in COVID-19 cases, bilateral multi-focal opacities are common. Computed tomography (CT) scans vary, but bilateral peripheral ground-glass opacities with consolidation in late disease stage, is common. The NIH cautioned that imaging may be normal early after infection, but can be abnormal in asymptomatic patients.

    "At present, no drug has been proven to be safe and effective for treating COVID-19.

    There are insufficient data to recommend either for or against the use of any antiviral or immunomodulatory therapy in patients with COVID-19 who have mild, moderate, severe, or critical illness," the NIH wrote in the guidelines.

    Most cases of COVID-19 have been mild, the NIH stated. In an analysis 72,314 cases of COVID-19 in China, 81% were mild, 14% were severe and 5% were critical. The condition disproportionately affects the elderly and people of any age who have uncontrolled hypertension, cardiovascular disease, diabetes, chronic respiratory disease, cancer, renal disease, and obesity.

    Treatment Recommendations for the Use of Antivirals for COVID-19

    There are insufficient clinical data to recommend either for or against the use of chloroquine, hydroxychloroquine or the investigational antiviral drug remdesivir due to insufficient clinical trials data.

    Except for within the context of a clinical trial, the combination of hydroxychloroquine plus azithromycin is not recommended due to potential toxicities.

    Lopinavir/ritonavir (or other HIV protease inhibitors) are not recommended due to unfavorable pharmacodynamics and negative clinical trial data.

    Host Modifiers/Immune-Based Therapy:

    Not recommended due to insufficient evidence: Convalescent plasma or hyperimmune immunoglobulin; interleukin-6 inhibitors (e.g., sarilumab, siltuximab, tocilizumab); Interleukin-1 inhibitors (e.g., anakinra); and, immunomodulators, such as interferons (due to toxicity and lack of efficacy in SARS and MERS cases); Janus kinase inhibitors (e.g., baricitinib) due to immunosuppressive effect.

    Angiotensin-Converting Enzyme (ACE) Inhibitors and Angiotensin Receptor Blockers (ARBs):

    These treatments should be continued in people who have been prescribed these treatments for cardiovascular disease or other indications.


    The recommendations for the use of corticosteroids differ considerably by patient and condition. But for rheumatology patients, oral corticosteroid therapy should not be discontinued. However, “on a case-by-case basis, supplemental or stress-dose steroids may be indicated.”

    Nonsteroidal Anti-Inflammatory Drugs (NSAIDs):

    Even in the presence of a confirmed COVID-19 diagnosis, NSAIDs typically taken for a co-morbid conditions should be continued as previously directed by a physician.

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  8. #8
    Senior Member JohnDoe2's Avatar
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    Last edited by JohnDoe2; 06-17-2020 at 08:48 PM.

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